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Age-related crossover in breast cancer incidence rates between black and white ethnic groups.

BACKGROUND: Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described,...

Sciences and the global: on methods, questions, and theory.

This essay explores the mechanics of researching and writing globally oriented histories of science. Thinking about how to approach sources is vital, especially given how often historians of science use the excuse of a lack of sources for constraining their projects to European...

A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.

Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the...

Large-scale patterns in biodiversity of microbial eukaryotes from the abyssal sea floor.

Eukaryotic microbial life at abyssal depths remains "uncharted territory" in eukaryotic microbiology. No phylogenetic surveys have focused on the largest benthic environment on this planet, the abyssal plains. Moreover, knowledge of the spatial patterns of deep-sea community...

Basic mathematical rules are encoded by primate prefrontal cortex neurons.

Mathematics is based on highly abstract principles, or rules, of how to structure, process, and evaluate numerical information. If and how mathematical rules can be represented by single neurons, however, has remained elusive. We therefore recorded the activity of individual...

Full distance-resolved folding energy landscape of one single protein molecule.

Kinetic bulk and single molecule folding experiments characterize barrier properties but the shape of folding landscapes between barrier top and native state is difficult to access. Here, we directly extract the full free energy landscape of a single molecule of the GCN4...

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