Journal Articles
Mar 11
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infect humans, causing sleeping...
Mar 9
It has recently been argued that a self-consistency condition involving the Jarzynski equality (JE) and the Crooks fluctuation theorem (CFT) is violated for a simple Brownian process [L. Y. Chen, J. Chem. Phys.129, 091101 (2008)]. This note adopts the definitions in the...
Feb 25
In computational thermodynamics, a sequence of intermediate states is commonly introduced to connect two equilibrium states. We consider two cases where the choice of intermediate states is particularly important: minimizing statistical error in free-energy difference...
Feb 18
We present fluorescence-detected measurements of the temperature-jump relaxation kinetics of the designed three-helix bundle protein alpha(3)D taken under solvent conditions identical to previous infrared-detected kinetics. The fluorescence-detected rate is similar to the...
Feb 10
This study examined the spatial and temporal limitations of the visual corrective process in the control of upper limb movements. Real-time calculation of kinematic data was used to trigger a prismatic displacement of the movement environment during manual aiming. Using an...
Feb 10
It would be hard to find a cosmologist today who does not believe that the vast bulk of the Universe (95% or more) is hidden from our eyes. We review the evidence for this remarkable consensus, and for the latest proposal, that the mysterious dark matter consists of as many as...
Feb 10
Bibliometric measures of individual scientific achievement are of particular interest if they can be used to predict future achievement. Here we report results of an empirical study of the predictive power of the h index compared with other indicators. Our findings indicate...
Feb 10
The discovery of mirror neurons has suggested a potential neural basis for simulation and common coding theories of action perception, theories which propose that we understand other people's actions because perceiving their actions activates some of our neurons in much the...
Feb 10
In traditional statistical methodology (e.g., the ANOVA), confidence in the observed results is often assessed by computing thep value or the power of the test. In most cases, adding more participants to a study will improve these measures more than will increasing the amount...
Feb 10
Normal mode analysis using elastic network models has grown popular for probing the low-frequency collective dynamics of proteins and other biomolecular assemblies. In most previous studies, these models were validated by comparing calculated atomic fluctuations for isolated...